2008

Journal of Virology - May 2008
Induction of Plasma (TRAIL), TNFR-2, Fas Ligand and Plasma Microparticles After HIV-1 Transmission: Implications for HIV-1 Vaccine Design.
Gasper-Smith N, Crossman DM, Whitesides JF, Mensali N, Ottinger JS, Plonk SG, Moody MA, Ferrari G, Weinhold KJ, Miller SE, Reich CF 3rd, Qin L, Self SG, Shaw GM, Denny TN, Jones LE, Pisetsky DS, Haynes BF.
J Virol. 2008 May 28. [Epub ahead of print] Abstract

 

Proceedings of the National Academy of Sciences - in press, 2008
Identification and Characterization of Transmitted and Early Founder Virus Envelopes in Primary HIV-1 Infection.
Keele BF, Giorgi EE, Salazar-Gonzalez J, Decker JM, Pham KT, Salazar MG, Sun C, Grayson T, Wang S, Li H, Wei X, Jiang C, Kirchherr JL, Gao F, Anderson JA, Ping L-H, Swanstrom R, Tomaras GD, Blattner WA, Goepfert PA, Kilby JM, Saag MS, Delwart EL, Busch MP, Cohen MS, Montefiori DC, Haynes BF, Gaschen B, Athreya GS, Lee HY, Wood N, Seoighe C, Perelson AS, Bhattacharya T, Korber BT, Hahn BH, Shaw GM.

Proceedings of the National Academy of Sciences. 2008 May 27. 105(21):7552-7. Abstract

 

Journal of Allergy & Clinical Immunology - in press, 2008
Critical Issues in mucosal immunity for HIV-1 vaccine development.
Haynes BF and Shattock RJ.
J. Aller & Clin Immunol. in press, 2008. Abstract

 

Proceedings of the National Academy of Sciences - in press, 2008
Centralized Gene-based HIV-1 Vaccine Elicits Broad Cross-clade Cellular Immune Responses in Rhesus Monkeys.

Santra S, Korber BT, Muldoon M, Barouch DH, Nabel GJ, Gao F, Hahn BH, Haynes BF, Letvin NL. 

Proceedings of the National Academy of Sciences. in press 2008. 

 

Journal of Virology - March 2008
4E10 Resistant Variants in an HIV-1 Subtype C Infected Individual with a Strong Anti-MPER Neutralizing Antibody Response.
Gray ES, Moore PL, Bibollet-Ruche F, Li H, Decker JM, Meyers T, Shaw GM, Morris L.
Journal of Virology. 2008 Mar. 82(5): 2367-75. Abstract

 

Proceedings of the National Academy of Sciences - March 2008

A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies.

Frey G, Peng H, Rits-Volloch S, Morelli M, Cheng Y, Chen B.
Proceedings of the National Academy of Sciences. 2008 Mar 11. 105(10): 3739-44. Abstract

 

Genome Research - March 2008
WGAViewer: Software for genomic annotation of whole genome association studies.
Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB.
Genome Res. 2008 Mar 3 [Epub ahead of print] Abstract

 

Journal of Virology - February 2008
The C3-V4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection.
Moore PL, Gray ES, Choge IA, Ranchobe N, Mlisana K, Abdool Karim SS, Williamson C, Morris L; CAPRISA 002 Study Team.
Journal of Virology. 2008 Feb. 82(4): 1860-9. Abstract

 

Journal of Virology - February 2008

Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single Genome Amplification and Sequencing.
Salazar-Gonzalez JF, Bailes E, Pham KT, Salazar MG, Guffey MB, Keele BF, Derdeyn CA, Farmer P, Hunter E, Allen S, Manigart O, Mulenga J, Anderson JA, Swanstrom R, Haynes BF, Athreya GS, Korber BT, Sharp PM, Shaw GM, Hahn BH.
Journal of Virology. 2008 Feb 6 [Epub ahead of print] Abstract

 

Immunity - January 2008
HIV hides an Achillees’ Heel in virion lipids.
Haynes BF and Alam SM.
Immunity. 2008 Jan. 28(1):10-2. Abstract

2007

Journal of Virology - in press, 2007

HIV-1 gp41 Antibodies That Mask Membrane Proximal Neutralizing Epitopes: Antibody Binding Kinetics, Induction And Potential For Regulation in Acute Infection.

Alam SM, Scearce R, Parks R, Plonk P, Plonk SG, Sutherland LL, Gorny MK,  Zolla-Pazner S, VanLeeuwen S, Moody MA, Xia S-X, Montefiori DC, Tomaras  GD, Weinhold KJ, Karim, SA, Hicks CB, Liao H-X, Robinson J, Shaw G.M., and Haynes BF.

J Virol. Epub 2007 Oct 17. Abstract

 

AIDS - in press, 2007

A risk score algorithm for detecting acute HIV-1 infection in an African STI clinic.

Powers KA, Miller WC, Pilcher CD, Mapanje C, Martinson FEA, Fiscus SA, Chilongozi D, Namakhwa D, Gama S, Price M, Galvin S, Hoffman I and Cohen MS.
AIDS. in press, 2007.

 

Current Opinion in HIV and AIDS - in press, 2007

Innate immune responses in primary HIV-1 infection.

Borrow P and Bhardwaj N.
Current Opinion in HIV and AIDS. in press, 2007.

 

Journal of Virology - December 2007
The impact of a boosting immunogen on the differentiation of secondary memory CD8+ T cells.
Hovav AH, Panas MW, Osuna CE, Cayabyab MJ, Autissier P, Letvin NL.
Journal of Virology. 2007 Dec. 81(23): 12793-802. Abstract

 

Journal of Immunology - November 2007
Duration of Antigen Expression In Vivo following DNA Immunization Modifies the Magnitude, Contraction, and Secondary Responses of CD8+ T Lymphocytes.

Hovav AH, Panas MW, Rahman S, Sircar P, Gillard G, Cayabyab MJ, Letvin NL.
Journal of Immunology. 2007 Nov 15. 179(10): 6725-33. Abstract

 

Science - September 2007
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD.
Science. 2007 Sep 28. 317(5846): 1930-4. Abstract

 

Nature Medicine - September 2007

Broad HIV-1 neutralization mediated by CD4-binding site antibodies.
Li Y, Migueles SA, Welcher B, Svehla K, Phogat A, Louder MK, Wu X, Shaw GM, Connors M, Wyatt RT, Mascola JR.
Nat Med. 2007 Sep. 13(9):1032-4.  Abstract

 

AIDS - August 2007
Amplified transmission of HIV-1: Comparison of HIV-1 concentrations in blood and semen in acute and chronic infection.
Pilcher CD, Joaki G, Hoffman IF, Martinson FEA, Mapanje C, Stewart PW, Powers KA, Galvin S, Chilongozi D, Gama S, Price MA, Fiscus SA, and Cohen MS.
AIDS. 2007 Aug 20. 21(13): 1723-30. Abstract

 

Journal of Acquired Immune Deficiency Syndromes - August 2007
Jones LE and Perelson AS.
Transient viremia and reservoir replenishment in HIV infected patients on antiretroviral therapy.
JAIDS. 2007 Aug 15. 45(5): 483-93. Abstract

 

Journal of Virology - August 2007

Memory CD4+ T-lymphocyte loss and dysfunction during primary simian immunodeficiency virus infection.

Sun Y, Permar, SR, Buzby, AP, Letvin, NL.
J Virol. 2007 Aug; 81(15):8009-15. Epub 2007 May 23. Abstract

 

Clinical and Experimental Immunology - August 2007
Acute HIV infection: the impact of anti-retroviral treatment on cellular immune responses.
Hicks CB, Gay C, and Ferrari G.
Clinical and Experimental Immunology. 2007 Aug. 149(2): 211-6. Abstract

 

Science - July 2007
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1.

Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB.
Science. 2007 Jul 19 [Epub ahead of print]. Abstract

Journal of Virological Methods - July 2007
High-throughput functional analysis of HIV-1 env genes without cloning.
Kirchherr JL, Lu X, Kasongo W, Chalwe V, Mwananyanda L, Musonda RM, Xia SM, Scearce RM, Liao HX, Montefiori DC, Haynes BF, Gao F.
Journal of Virological Methods. 2007 Jul. 143(1): 104-11. Abstract 

 

Journal of Virology – July 2007

Effects of type I interferons on the adjuvant properties of plasmid GM-CSF in vivo. 

Qin, L, Greenland, JR, Moriya, C, Cayabyab, MJ, Letvin, NL. 
J. Virol. 2007 Oct 81(19):10606-13. Epub July 25. Abstract

 

Current Biology - July 2007
Host genetics: fine-tuning innate signaling.
Fellay J and Goldstein DB.
Curr Biol. 2007 Jul 3. 17(13): R516-8. Abstract

 

Journal of Virology - June 2007
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human Immunodeficiency Virus Type 1-infected donors.

Dhillon AK, Donners H, Pantophlet R, Johnson WE, Decker JM, Shaw GM, Lee FH, Richman DD, Doms RW, Vanham G, Burton DR.
Journal of Virology. 2007 Jun. 81(12): 6548-62. Abstract

 

Journal of Virology – June 2007

Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection.

Gray ES, Moore PL, Choge IA, Decker JM, Bibollet-Ruche F, Li H, Leseka N, Treurnicht F, Mlisana K, Shaw GM, Karim SS, Williamson C, Morris L.

Journal of Virology. 2007 Jun. 81(12):6187-96. Epub 2007 Apr 4. Abstract

 

Journal of Virology - June 2007

Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics and immunogenicity.

Dey B, Pancera M, Svehla K, Shu Y, Xiang SH, Vainshtein J, Li Y, Sodroski J, Kwong PD, Mascola JR, Wyatt R.
Journal of Virology. 2007 Jun. 81(11): 5579-93. Abstract

 

Journal of Immunology - May 2007

Plasmid DNA vaccine –elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis.

Greenland, JR, Geiben, R, Ghosh, S, Pastor, WA, Letvin, NL.
J. Immunol. 178: 5652-5658, 2007. Abstract

 

Blood – May 2007

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.

Wilson TJ, Presti RM, Tassi I, Overton ET, Cella M, Colonna M.

Blood. 2007 May 1. 109(9):3786-93. Epub 2007 Jan 9. Abstract

 

Journal of Immunology - April 2007

The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes.

Alam SM, McAdams M, Boren D, Rak M, Scearce RM, Gao F, Comacho ZT, Gewirth D, Kelsoe G, Chen P, Haynes BF. 
J. Immunol 178: 4424-35, 2007. Abstract 

 

Virology - March 2007

Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins.

Kothe DL, Decker JM, Li Y, Weng Z, Bibollet-Ruche F, Zammit KP, Salazar MG, Chen Y, Salazar-Gonzalez JF, Moldoveanu Z, Mestecky J, Gao F, Haynes BF, Shaw GM, Muldoon M, Korber BT, Hahn BH.
Virology. 2007 Mar 30. 360(1): 218-34. Abstract

 

Nature - February 2007
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD.
Nature. 2007 Feb 15. 445(7129): 732-7. Abstract

 

Journal of Virology - January 2007

Rapid Memory CD8+ T-Lymphocyte Induction through Priming with Recombinant Mycobacterium smegmatis.

Hovav AH, Cayabyab MJ, Panas MW, Santra S, Greenland J, Geiben R, Haynes BF, Jacobs WR Jr, Letvin NL.
Journal of Virology. 2007 Jan. 81(1): 74-83. Abstract

2006

Nature Reviews. Microbiology – November 2006

Genomics meets HIV-1.

Telenti A, Goldstein DB.

Nature Reviews. Microbiology. 2006 Nov. 4(11):865-73. Epub 2006 Oct 9. Abstract

Expert Review of Vaccines - August 2006

Aiming to Induce Broadly Reactive Neutralizing Antibody Responses with HIV-1 Vaccine Candidates. 

Haynes BF and Montefiori DC. 

Expert Review of Vaccines. 2006 Aug;5(4):579-595. Abstract

2005

Human Antibodies - 2005

Antibody polyspecificity and neutralization of HIV-1: A hypothesis.

Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM.

Human Antibodies. 2005; 14(3-4):59-67. Abstract

 

Journal of Clinical Immunology - September 2005

Naive T cells are maintained in the periphery during the first 3 months of acute HIV-1 infection: implications for analysis of thymus function.

Sempowski GD, Hicks CB, Eron JJ, Bartlett JA, Hale LP, Ferrari G, Edwards LJ, Fiscus S, Haynes BF. 

Journal of Clinical Immunology. 2005 Sep; 25(5): 462-72. Abstract